Scientists reveal new TEV-mediated αPD-L1-specific therapy resistance mechanism

by Zhejiang UniversityTEV PD-L1 competes with PD-L1 on tumor cells to bind αPD-L1.a,bMC38-EVs and PC3-EVs (1 μg) (a) or MC38 and PC3 cells (1 × 105) (b) were coincubated with the ind

Updated on: December 27,2023 12

Scientists reveal new TEV-mediated αPD-L1-specific therapy resistance mechanism

by Zhejiang UniversityTEV PD-L1 competes with PD-L1 on tumor cells to bind αPD-L1.a,bMC38-EVs and PC3-EVs (1 μg) (a) or MC38 and PC3 cells (1 × 105) (b) were coincubated with the ind

Updated on:December 27,2023 12

AI-based analysis identifies two plant extracts with potential as GLP-1 agonist weight loss pills

by European Association for the Study of ObesityCredit: AI-generated imageTwo plant compounds with potential as GLP-1 agonist weight loss pills have been identified in an AI (artificial intelligence)-

Updated on: March 28,2024 0

AI-based analysis identifies two plant extracts with potential as GLP-1 agonist weight loss pills

by European Association for the Study of ObesityCredit: AI-generated imageTwo plant compounds with potential as GLP-1 agonist weight loss pills have been identified in an AI (artificial intelligence)-

Updated on:March 28,2024 0

Drug candidate granted FDA orphan drug status for pancreatic cancer

by Roswell Park Comprehensive Cancer CenterCredit:Journal of Medicinal Chemistry(2023). DOI: 10.1021/acs.jmedchem.3c01589The U.S. Food and Drug Administration (FDA) has awarded Orphan Drug

Updated on: April 23,2024 14

Drug candidate granted FDA orphan drug status for pancreatic cancer

by Roswell Park Comprehensive Cancer CenterCredit:Journal of Medicinal Chemistry(2023). DOI: 10.1021/acs.jmedchem.3c01589The U.S. Food and Drug Administration (FDA) has awarded Orphan Drug

Updated on:April 23,2024 14

Can HIV be cured using gene editing? We may soon find out

by Kalpana Surendranath,The ConversationCredit: Pixabay/CC0 Public DomainHIV, the virus that causes AIDS, was firstidentified in 1983. To catch this virus was initially a death sentence, b

Updated on: January 04,2024 12

Can HIV be cured using gene editing? We may soon find out

by Kalpana Surendranath,The ConversationCredit: Pixabay/CC0 Public DomainHIV, the virus that causes AIDS, was firstidentified in 1983. To catch this virus was initially a death sentence, b

Updated on:January 04,2024 12

Anesthesia technology precisely controls unconsciousness in animal tests

byMassachusetts Institute of TechnologySchematic of the propofol-based CLAD system for control of unconsciousness in an NHP. The user sets the target level of the marker of unconsciousness (MOU)

Updated on: January 04,2024 10

Anesthesia technology precisely controls unconsciousness in animal tests

byMassachusetts Institute of TechnologySchematic of the propofol-based CLAD system for control of unconsciousness in an NHP. The user sets the target level of the marker of unconsciousness (MOU)

Updated on:January 04,2024 10

Anti-aging drug rapamycin found to improve immune function through endolysosomes

by Max Planck SocietyRapamycin is one of the most promising anti-aging substances to date. Rapamycin is named after "Rapa Nui," the local translation for the Easter Islands, where the a

Updated on: April 02,2024 11

Anti-aging drug rapamycin found to improve immune function through endolysosomes

by Max Planck SocietyRapamycin is one of the most promising anti-aging substances to date. Rapamycin is named after "Rapa Nui," the local translation for the Easter Islands, where the a

Updated on:April 02,2024 11

New prescription drugs typically sold first in US: Report

by RAND CorporationCredit: Pixabay/CC0 Public DomainMost new prescription drugs are sold first in the U.S. before they reach other nations, but ultimately important medications are sold across mo

Updated on: May 11,2024 4

New prescription drugs typically sold first in US: Report

by RAND CorporationCredit: Pixabay/CC0 Public DomainMost new prescription drugs are sold first in the U.S. before they reach other nations, but ultimately important medications are sold across mo

Updated on:May 11,2024 4

Natural products used in Ayurvedic treatments alleviate symptoms of depression in fruit flies

by Kathrin Voigt,Johannes Gutenberg University MainzThe level of motivation of the fruit fly Drosophila can be deduced on the basis of whether it attempts to climb over gaps it encounters when w

Updated on: May 05,2024 17

Natural products used in Ayurvedic treatments alleviate symptoms of depression in fruit flies

by Kathrin Voigt,Johannes Gutenberg University MainzThe level of motivation of the fruit fly Drosophila can be deduced on the basis of whether it attempts to climb over gaps it encounters when w

Updated on:May 05,2024 17

Damaged nerve cells communicate with stem cells

Nerve cells damaged in diseases such as multiple sclerosis (MS), 'talk' to stem cells in the same way that they communicate with other nerve cells, calling out for 'first aid', accordi

Updated on: November 02,2023 10

Damaged nerve cells communicate with stem cells

Nerve cells damaged in diseases such as multiple sclerosis (MS), 'talk' to stem cells in the same way that they communicate with other nerve cells, calling out for 'first aid', accordi

Updated on:November 02,2023 10

Pig Organ Transplants: Hope and Progress in Xenotransplantation

Updated on: May 25,2024 0

Pig Organ Transplants: Hope and Progress in Xenotransplantation

Updated on:May 25,2024 0

New tool unifies single-cell data for the global research community

by Rachael Smith,Wellcome Trust Sanger InstituteGraphical Abstract. Credit:Cell(2023). DOI: 10.1016/j.cell.2023.11.026A new methodology that allows for the categorization and organiz

Updated on: December 26,2023 12

New tool unifies single-cell data for the global research community

by Rachael Smith,Wellcome Trust Sanger InstituteGraphical Abstract. Credit:Cell(2023). DOI: 10.1016/j.cell.2023.11.026A new methodology that allows for the categorization and organiz

Updated on:December 26,2023 12

UTI drug gepotidacin performs well in clinical trials compared to nitrofurantoin

by Bob Yirka , Medical XpressCredit: Pixabay/CC0 Public DomainA team of medical researchers with affiliations to British multinational pharmaceutical and biotechnology company GlaxoSmithKline (GSK) ha

Updated on: March 21,2024 19

UTI drug gepotidacin performs well in clinical trials compared to nitrofurantoin

by Bob Yirka , Medical XpressCredit: Pixabay/CC0 Public DomainA team of medical researchers with affiliations to British multinational pharmaceutical and biotechnology company GlaxoSmithKline (GSK) ha

Updated on:March 21,2024 19