Gene loss enhances metastasis and cancer progression

by Melissa Rohman,Northwestern UniversityAn in vivo genome-wide CRISPR-Cas9 KO screen identifying CTC-promoting genetic factors. (A) Experimental design of the genome-wide CRISPR-Cas9 KO screen

Updated on: December 25,2023 5

Gene loss enhances metastasis and cancer progression

by Melissa Rohman,Northwestern UniversityAn in vivo genome-wide CRISPR-Cas9 KO screen identifying CTC-promoting genetic factors. (A) Experimental design of the genome-wide CRISPR-Cas9 KO screen

Updated on:December 25,2023 5

Genetic discovery could improve treatment of colorectal cancer

by Rémi Carlier,Ecole Polytechnique Federale de LausannePOU5F1B differs from OCT4. a Representative immunofluorescence–confocal microscopy of POU5F1B-HA overexpressing SW480 cells, with DAPI in

Updated on: December 25,2023 10

Genetic discovery could improve treatment of colorectal cancer

by Rémi Carlier,Ecole Polytechnique Federale de LausannePOU5F1B differs from OCT4. a Representative immunofluorescence–confocal microscopy of POU5F1B-HA overexpressing SW480 cells, with DAPI in

Updated on:December 25,2023 10

Gene and cell therapies to combat pancreatic cancer

byMary Ann Liebert, IncGTMP clinical trials for pancreatic cancer depending on phase and trial status. Source: Clinical trial.gov. GTMPs, gene therapy medicinal products. Credit:Human Gene

Updated on: December 25,2023 6

Gene and cell therapies to combat pancreatic cancer

byMary Ann Liebert, IncGTMP clinical trials for pancreatic cancer depending on phase and trial status. Source: Clinical trial.gov. GTMPs, gene therapy medicinal products. Credit:Human Gene

Updated on:December 25,2023 6

Genetic tests create treatment opportunities and confusion for breast cancer patients

by Michelle AndrewsCredit: Pixabay/CC0 Public DomainThe past decade has witnessed a rapid expansion of genetic tests, including new instruments to inform patients who have been diagnosed with breast c

Updated on: December 25,2023 8

Genetic tests create treatment opportunities and confusion for breast cancer patients

by Michelle AndrewsCredit: Pixabay/CC0 Public DomainThe past decade has witnessed a rapid expansion of genetic tests, including new instruments to inform patients who have been diagnosed with breast c

Updated on:December 25,2023 8

Genetic test could guide use of cancer chemotherapy

by Ellie Cawthera,Imperial College LondonDiscovery ofKRASG12mutation status as potential biomarker of outcome of FTD/TPI treatment in mCRC.a, Dot plot showing the associations

Updated on: December 25,2023 9

Genetic test could guide use of cancer chemotherapy

by Ellie Cawthera,Imperial College LondonDiscovery ofKRASG12mutation status as potential biomarker of outcome of FTD/TPI treatment in mCRC.a, Dot plot showing the associations

Updated on:December 25,2023 9

Genes reveal kidney cancer's risk of recurrence

byMcGill UniversityDisease-Free Survival outcomes amongst genomic groups when applied to the 247 VHL mutated ccRCCs from the TCGA dataset. Credit:Clinical Cancer Research(2023). DOI:

Updated on: December 25,2023 13

Genes reveal kidney cancer's risk of recurrence

byMcGill UniversityDisease-Free Survival outcomes amongst genomic groups when applied to the 247 VHL mutated ccRCCs from the TCGA dataset. Credit:Clinical Cancer Research(2023). DOI:

Updated on:December 25,2023 13

Gene interactions classify bowel tumors for personalized medicine

byeLifeFlowchart of the interaction-perturbation-based program. As an example, the background network consists of six genes and five interactions. There were three normal samples (yellow) and th

Updated on: December 25,2023 9

Gene interactions classify bowel tumors for personalized medicine

byeLifeFlowchart of the interaction-perturbation-based program. As an example, the background network consists of six genes and five interactions. There were three normal samples (yellow) and th

Updated on:December 25,2023 9

The way genes are switched on in one-cell embryos may resemble the trigger for cancer

byUniversity of BathGraphical Abstract. Credit:Cell Reports(2023). DOI: 10.1016/j.celrep.2023.112023When an embryo is formed, its genes—donated by a fertilizing sperm and egg—are sil

Updated on: December 25,2023 9

The way genes are switched on in one-cell embryos may resemble the trigger for cancer

byUniversity of BathGraphical Abstract. Credit:Cell Reports(2023). DOI: 10.1016/j.celrep.2023.112023When an embryo is formed, its genes—donated by a fertilizing sperm and egg—are sil

Updated on:December 25,2023 9

How genetics play a role in developing melanoma

byCleveland ClinicCredit: Pixabay/CC0 Public DomainA recent study from Cleveland Clinic shows that melanoma, which is the most serious type of skin cancer, isn't just caused by environmental

Updated on: December 25,2023 9

How genetics play a role in developing melanoma

byCleveland ClinicCredit: Pixabay/CC0 Public DomainA recent study from Cleveland Clinic shows that melanoma, which is the most serious type of skin cancer, isn't just caused by environmental

Updated on:December 25,2023 9

Genomic assay may predict long-term prognosis in premenopausal patients with HR-positive early-stage breast cancer

byAmerican Association for Cancer ResearchThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in

Updated on: December 25,2023 10

Genomic assay may predict long-term prognosis in premenopausal patients with HR-positive early-stage breast cancer

byAmerican Association for Cancer ResearchThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in

Updated on:December 25,2023 10

How genome doubling helps cancer develop

byEcole Polytechnique Federale de LausanneChromosomes in cells with whole genome doubling. Credit: Elisa Oricchio/Giovanni Ciriello (EPFL/UNIL)A single cell contains 2-3 meters of DNA, meaning t

Updated on: December 25,2023 9

How genome doubling helps cancer develop

byEcole Polytechnique Federale de LausanneChromosomes in cells with whole genome doubling. Credit: Elisa Oricchio/Giovanni Ciriello (EPFL/UNIL)A single cell contains 2-3 meters of DNA, meaning t

Updated on:December 25,2023 9

Genomic testing can identify African American prostate cancer patients who have high-risk disease

byH. Lee Moffitt Cancer Center & Research InstituteCredit: Unsplash/CC0 Public DomainAfrican American men tend to be diagnosed more frequently with prostate cancer and have higher mortality

Updated on: December 25,2023 9

Genomic testing can identify African American prostate cancer patients who have high-risk disease

byH. Lee Moffitt Cancer Center & Research InstituteCredit: Unsplash/CC0 Public DomainAfrican American men tend to be diagnosed more frequently with prostate cancer and have higher mortality

Updated on:December 25,2023 9