An infamous 'inflammasome'—a rogue protein complex—appears to underlie a rare and disabling autoimmune disorder

by Delthia Ricks , Medical XpressCa2+ influx is required for PIEZO-dependent NLRP3 inflammasome activation. Credit:Science Immunology(2023). DOI: 10.1126/sciimmunol.adf4699Autoimmune disea

Updated on: March 30,2024

An infamous 'inflammasome'—a rogue protein complex—appears to underlie a rare and disabling autoimmune disorder

by Delthia Ricks , Medical XpressCa2+ influx is required for PIEZO-dependent NLRP3 inflammasome activation. Credit:Science Immunology(2023). DOI: 10.1126/sciimmunol.adf4699Autoimmune disea

Updated on:March 30,2024

Risk of severe breakthrough COVID-19 infection is higher for people with HIV with moderately low CD4 cell counts

by Johns Hopkins University Bloomberg School of Public HealthGraphs show incidence of severe COVID-19 breakthrough illness by HIV status (A) (log-rank test P = .40), by CD4 cell count and HIV sta

Updated on: April 09,2024

Risk of severe breakthrough COVID-19 infection is higher for people with HIV with moderately low CD4 cell counts

by Johns Hopkins University Bloomberg School of Public HealthGraphs show incidence of severe COVID-19 breakthrough illness by HIV status (A) (log-rank test P = .40), by CD4 cell count and HIV sta

Updated on:April 09,2024

Frailty may be reversible for some people with rheumatoid arthritis

by University of GlasgowCredit: Unsplash/CC0 Public DomainRheumatoid arthritis patients living with frailty may find their frailty is reversible following treatment, according to a new study.The

Updated on: June 26,2024

Frailty may be reversible for some people with rheumatoid arthritis

by University of GlasgowCredit: Unsplash/CC0 Public DomainRheumatoid arthritis patients living with frailty may find their frailty is reversible following treatment, according to a new study.The

Updated on:June 26,2024

How an emerging drug class dampens harmful immune reactions

by Angelika Jacobs,University of BaselOverview of complement mechanisms and compstatin-based inhibitor development.aSimplified scheme of the complement cascade with major effector fu

Updated on: March 25,2024

How an emerging drug class dampens harmful immune reactions

by Angelika Jacobs,University of BaselOverview of complement mechanisms and compstatin-based inhibitor development.aSimplified scheme of the complement cascade with major effector fu

Updated on:March 25,2024

Team explores role of 'stimulator of interferon genes' in body's innate immune system

by Tokai National Higher Education and Research SystemA graphical illustration of cholesterol- and palmitoylation-dependent STING clustering at the TGN. Credit: Institute for Glyco-core ResearchWhen p

Updated on: June 18,2024

Team explores role of 'stimulator of interferon genes' in body's innate immune system

by Tokai National Higher Education and Research SystemA graphical illustration of cholesterol- and palmitoylation-dependent STING clustering at the TGN. Credit: Institute for Glyco-core ResearchWhen p

Updated on:June 18,2024

Common sites of bone erosion in rheumatoid arthritis

(HealthDay)—Joint recesses with bone erosion are more likely to exhibit greater severity of joint inflammation on ultrasound (US) examination, according to a study published online Oct. 25 in the&nbsp

Updated on: May 08,2024

Common sites of bone erosion in rheumatoid arthritis

(HealthDay)—Joint recesses with bone erosion are more likely to exhibit greater severity of joint inflammation on ultrasound (US) examination, according to a study published online Oct. 25 in the&nbsp

Updated on:May 08,2024

New understanding of the gut immune system may hold promise for Crohn's disease patients

by Technical University of DenmarkCredit: Pixabay/CC0 Public DomainTricks played by certain disease-driving gut bacteria might help explain differences in how patients experience Crohn's dise

Updated on: March 19,2024

New understanding of the gut immune system may hold promise for Crohn's disease patients

by Technical University of DenmarkCredit: Pixabay/CC0 Public DomainTricks played by certain disease-driving gut bacteria might help explain differences in how patients experience Crohn's dise

Updated on:March 19,2024

Meat, multiple sclerosis and the microbiome

by University of ConnecticutCredit: Pixabay/CC0 Public DomainEating more meat, having less of certain bacteria in the gut, and more of certain immune cells in the blood, all link with multiple sc

Updated on: May 26,2024

Meat, multiple sclerosis and the microbiome

by University of ConnecticutCredit: Pixabay/CC0 Public DomainEating more meat, having less of certain bacteria in the gut, and more of certain immune cells in the blood, all link with multiple sc

Updated on:May 26,2024

Passive smoking linked to increased risk of rheumatoid arthritis

Passive smoking during childhood and/or adulthood is associated with increased risk of rheumatoid arthritis (RA), according to a study recently published inRMD Open.Yann Nguyen, M.D., M.P.H., fr

Updated on: June 06,2024

Passive smoking linked to increased risk of rheumatoid arthritis

Passive smoking during childhood and/or adulthood is associated with increased risk of rheumatoid arthritis (RA), according to a study recently published inRMD Open.Yann Nguyen, M.D., M.P.H., fr

Updated on:June 06,2024

Systemic inflammation increases risk for chronic kidney disease

by Lori SolomonSystemic inflammation is associated with an elevated risk for chronic kidney disease, according to a study published online Feb. 20 inFrontiers in Immunology.Xiaoxin Liu, from Ton

Updated on: April 30,2024

Systemic inflammation increases risk for chronic kidney disease

by Lori SolomonSystemic inflammation is associated with an elevated risk for chronic kidney disease, according to a study published online Feb. 20 inFrontiers in Immunology.Xiaoxin Liu, from Ton

Updated on:April 30,2024

Researchers develop statistical method for genetic mapping of autoimmune diseases

byBrigham and Women’s HospitalSchematic overview of SCENT and SCENT enhancer–gene pairs across nine single-cell multimodal datasets.a, SCENT identifies (1) activecis-regulatory regio

Updated on: April 27,2024

Researchers develop statistical method for genetic mapping of autoimmune diseases

byBrigham and Women’s HospitalSchematic overview of SCENT and SCENT enhancer–gene pairs across nine single-cell multimodal datasets.a, SCENT identifies (1) activecis-regulatory regio

Updated on:April 27,2024

10 percent of US adults physically limited by arthritis, CDC reports

by Steven Reinberg, Healthday ReporterExperts say obesity epidemic has widened the pool of disabled.(HealthDay)—More than 50 million Americans have arthritis, and almost half of them can't perform

Updated on: March 24,2024

10 percent of US adults physically limited by arthritis, CDC reports

by Steven Reinberg, Healthday ReporterExperts say obesity epidemic has widened the pool of disabled.(HealthDay)—More than 50 million Americans have arthritis, and almost half of them can't perform

Updated on:March 24,2024