An infamous 'inflammasome'—a rogue protein complex—appears to underlie a rare and disabling autoimmune disorder

by Delthia Ricks , Medical XpressCa2+ influx is required for PIEZO-dependent NLRP3 inflammasome activation. Credit:Science Immunology(2023). DOI: 10.1126/sciimmunol.adf4699Autoimmune disea

Updated on: March 30,2024

An infamous 'inflammasome'—a rogue protein complex—appears to underlie a rare and disabling autoimmune disorder

by Delthia Ricks , Medical XpressCa2+ influx is required for PIEZO-dependent NLRP3 inflammasome activation. Credit:Science Immunology(2023). DOI: 10.1126/sciimmunol.adf4699Autoimmune disea

Updated on:March 30,2024

Among allergic conditions, food allergy found to have highest risk of developing eosinophilic esophagitis

byAmerican College of Allergy, Asthma, and ImmunologyCredit: Unsplash/CC0 Public DomainEosinophilic esophagitis (EoE), a disorder of the esophagus, is increasingly recognized as a major cause of

Updated on: November 01,2024

Among allergic conditions, food allergy found to have highest risk of developing eosinophilic esophagitis

byAmerican College of Allergy, Asthma, and ImmunologyCredit: Unsplash/CC0 Public DomainEosinophilic esophagitis (EoE), a disorder of the esophagus, is increasingly recognized as a major cause of

Updated on:November 01,2024

Study advances understanding of liver immune response in cirrhosis

byMiguel Hernandez University of ElcheLSECtin expression in the liver inversely correlates with Th17 expansion in cirrhosis. (A) Representative Immunohistochemistry of the lymphocyte-specific tr

Updated on: April 28,2024

Study advances understanding of liver immune response in cirrhosis

byMiguel Hernandez University of ElcheLSECtin expression in the liver inversely correlates with Th17 expansion in cirrhosis. (A) Representative Immunohistochemistry of the lymphocyte-specific tr

Updated on:April 28,2024

Immunity after COVID-19 illness may last at least 1 year

by Ernie MundellLong-term data from northern Italy—an area hit hard during the early days of the pandemic—suggests that reinfection after recovery from COVID-19 infection is very rare, and immunity in

Updated on: April 10,2024

Immunity after COVID-19 illness may last at least 1 year

by Ernie MundellLong-term data from northern Italy—an area hit hard during the early days of the pandemic—suggests that reinfection after recovery from COVID-19 infection is very rare, and immunity in

Updated on:April 10,2024

Systemic inflammation increases risk for chronic kidney disease

by Lori SolomonSystemic inflammation is associated with an elevated risk for chronic kidney disease, according to a study published online Feb. 20 inFrontiers in Immunology.Xiaoxin Liu, from Ton

Updated on: April 30,2024

Systemic inflammation increases risk for chronic kidney disease

by Lori SolomonSystemic inflammation is associated with an elevated risk for chronic kidney disease, according to a study published online Feb. 20 inFrontiers in Immunology.Xiaoxin Liu, from Ton

Updated on:April 30,2024

How an emerging drug class dampens harmful immune reactions

by Angelika Jacobs,University of BaselOverview of complement mechanisms and compstatin-based inhibitor development.aSimplified scheme of the complement cascade with major effector fu

Updated on: March 25,2024

How an emerging drug class dampens harmful immune reactions

by Angelika Jacobs,University of BaselOverview of complement mechanisms and compstatin-based inhibitor development.aSimplified scheme of the complement cascade with major effector fu

Updated on:March 25,2024

Passive smoking linked to increased risk of rheumatoid arthritis

Passive smoking during childhood and/or adulthood is associated with increased risk of rheumatoid arthritis (RA), according to a study recently published inRMD Open.Yann Nguyen, M.D., M.P.H., fr

Updated on: June 06,2024

Passive smoking linked to increased risk of rheumatoid arthritis

Passive smoking during childhood and/or adulthood is associated with increased risk of rheumatoid arthritis (RA), according to a study recently published inRMD Open.Yann Nguyen, M.D., M.P.H., fr

Updated on:June 06,2024

A plant-based compound that inhibits reactivation of the HIV viral reservoir, giving the immune system a break

by The Wistar InstituteOverview of HIV inhibitor screening strategy and identification of (–)-hopeaphenol. (A) Representative flow cytometry examples of HIV-GFP reporter expression in unstimulate

Updated on: May 05,2024

A plant-based compound that inhibits reactivation of the HIV viral reservoir, giving the immune system a break

by The Wistar InstituteOverview of HIV inhibitor screening strategy and identification of (–)-hopeaphenol. (A) Representative flow cytometry examples of HIV-GFP reporter expression in unstimulate

Updated on:May 05,2024

Common sites of bone erosion in rheumatoid arthritis

(HealthDay)—Joint recesses with bone erosion are more likely to exhibit greater severity of joint inflammation on ultrasound (US) examination, according to a study published online Oct. 25 in the&nbsp

Updated on: May 08,2024

Common sites of bone erosion in rheumatoid arthritis

(HealthDay)—Joint recesses with bone erosion are more likely to exhibit greater severity of joint inflammation on ultrasound (US) examination, according to a study published online Oct. 25 in the&nbsp

Updated on:May 08,2024

How much of a boost do 'booster' COVID-19 jabs give?

by King's College LondonCredit: Pixabay/CC0 Public DomainScientists have found the "booster" COVID-19 vaccine program led to a large boost in the antibodies that help protect agains

Updated on: March 13,2024

How much of a boost do 'booster' COVID-19 jabs give?

by King's College LondonCredit: Pixabay/CC0 Public DomainScientists have found the "booster" COVID-19 vaccine program led to a large boost in the antibodies that help protect agains

Updated on:March 13,2024

Indoor allergens worsen respiratory infections in children with asthma, study finds

byUniversity of Texas at AustinCredit: Andrea Piacquadio from PexelsChildren with asthma who are exposed to high levels of indoor allergens, such as cockroach and mouse allergens, are at an incr

Updated on: September 18,2024

Indoor allergens worsen respiratory infections in children with asthma, study finds

byUniversity of Texas at AustinCredit: Andrea Piacquadio from PexelsChildren with asthma who are exposed to high levels of indoor allergens, such as cockroach and mouse allergens, are at an incr

Updated on:September 18,2024

Frailty may be reversible for some people with rheumatoid arthritis

by University of GlasgowCredit: Unsplash/CC0 Public DomainRheumatoid arthritis patients living with frailty may find their frailty is reversible following treatment, according to a new study.The

Updated on: June 26,2024

Frailty may be reversible for some people with rheumatoid arthritis

by University of GlasgowCredit: Unsplash/CC0 Public DomainRheumatoid arthritis patients living with frailty may find their frailty is reversible following treatment, according to a new study.The

Updated on:June 26,2024