ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on: June 06,2024

ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on:June 06,2024

Disease control, safe medications critical to pregnancies for women with rheumatic disease

by UT Southwestern Medical CenterCredit: Pixabay/CC0 Public DomainPregnant women with active rheumatic disease carry a higher risk of adverse outcomes than the general population including hypert

Updated on: June 17,2024

Disease control, safe medications critical to pregnancies for women with rheumatic disease

by UT Southwestern Medical CenterCredit: Pixabay/CC0 Public DomainPregnant women with active rheumatic disease carry a higher risk of adverse outcomes than the general population including hypert

Updated on:June 17,2024

Secondary structures in DNA are associated with cancer

by Lila Reynolds,Northwestern UniversityCredit: CC0 Public DomainA new cancer study reports that DNA manifested as knot-like folds and third rungs between DNA's two strands may drive cancer

Updated on: April 15,2024

Secondary structures in DNA are associated with cancer

by Lila Reynolds,Northwestern UniversityCredit: CC0 Public DomainA new cancer study reports that DNA manifested as knot-like folds and third rungs between DNA's two strands may drive cancer

Updated on:April 15,2024

Combination of LABA + inhaled glucocorticoid safe in asthma

(HealthDay)—Compared to treatment with an inhaled glucocorticoid alone, combination therapy with a long-acting β2-agonist (LABA) and an inhaled glucocorticoid is not associated with a significantly hi

Updated on: April 16,2024

Combination of LABA + inhaled glucocorticoid safe in asthma

(HealthDay)—Compared to treatment with an inhaled glucocorticoid alone, combination therapy with a long-acting β2-agonist (LABA) and an inhaled glucocorticoid is not associated with a significantly hi

Updated on:April 16,2024

Treatment options for patients whose blood cancer relapses after CAR-T cell therapy

by The Mount Sinai HospitalCredit: Pixabay/CC0 Public DomainMount Sinai and Memorial Sloan Kettering Cancer Center (MSK) researchers have identified therapies that can help patients with the bloo

Updated on: April 09,2024

Treatment options for patients whose blood cancer relapses after CAR-T cell therapy

by The Mount Sinai HospitalCredit: Pixabay/CC0 Public DomainMount Sinai and Memorial Sloan Kettering Cancer Center (MSK) researchers have identified therapies that can help patients with the bloo

Updated on:April 09,2024

Time change for biological aging clocks: How immune cells shape our body's true age

by Dartmouth HealthThe association between immune cell composition and EAA for Horvath, Hannum, Pheno, and Zhang, DunedinPACE, and EpiTOC2 TNSC clocks across three age groups (0, 0–18, 18–99). Se

Updated on: March 07,2024

Time change for biological aging clocks: How immune cells shape our body's true age

by Dartmouth HealthThe association between immune cell composition and EAA for Horvath, Hannum, Pheno, and Zhang, DunedinPACE, and EpiTOC2 TNSC clocks across three age groups (0, 0–18, 18–99). Se

Updated on:March 07,2024

Updated recommendations for psoriatic arthritis

by European Alliance of Associations for Rheumatology, EULARCredit: Unsplash/CC0 Public DomainPsoriatic arthritis (PsA) is an autoimmune inflammatory disease. It has both joint and non-joint symptoms

Updated on: March 27,2024

Updated recommendations for psoriatic arthritis

by European Alliance of Associations for Rheumatology, EULARCredit: Unsplash/CC0 Public DomainPsoriatic arthritis (PsA) is an autoimmune inflammatory disease. It has both joint and non-joint symptoms

Updated on:March 27,2024

Skin must develop tolerance to 'good' bacteria early in life, says new study

by Pete Farley,University of California, San FranciscoHuman skin structure. Credit: WikipediaA wave of specialized immune cells entering the skin in early life may induce tolerance to the hundre

Updated on: April 24,2024

Skin must develop tolerance to 'good' bacteria early in life, says new study

by Pete Farley,University of California, San FranciscoHuman skin structure. Credit: WikipediaA wave of specialized immune cells entering the skin in early life may induce tolerance to the hundre

Updated on:April 24,2024

Non-surgical treatment significantly reduces knee pain for adults, especially those 50 and older

by The Reis GroupCredit: Pixabay/CC0 Public DomainGenicular nerve radiofrequency ablation is a minimally invasive treatment for knee pain due to osteoarthritis of the knee, and can significantly reduc

Updated on: May 23,2024

Non-surgical treatment significantly reduces knee pain for adults, especially those 50 and older

by The Reis GroupCredit: Pixabay/CC0 Public DomainGenicular nerve radiofrequency ablation is a minimally invasive treatment for knee pain due to osteoarthritis of the knee, and can significantly reduc

Updated on:May 23,2024

Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses

byUniversity of CambridgeBiochemist Professor Anne Willis and immunologist Dr James Thaventhiran at the MRC Toxicology Unit at the University of Cambridge led this work. Credit: Mike Thornton, S

Updated on: January 26,2024

Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses

byUniversity of CambridgeBiochemist Professor Anne Willis and immunologist Dr James Thaventhiran at the MRC Toxicology Unit at the University of Cambridge led this work. Credit: Mike Thornton, S

Updated on:January 26,2024

St18 is a negative regulator of VEGF

by National Institutes of Natural SciencesSt18 inhibits VEGF expression via Sp1 suppression. Credit: Kenta MaruyamaPro-inflammatory cytokines and pathogen-associated molecular patterns such as lipopol

Updated on: April 22,2024

St18 is a negative regulator of VEGF

by National Institutes of Natural SciencesSt18 inhibits VEGF expression via Sp1 suppression. Credit: Kenta MaruyamaPro-inflammatory cytokines and pathogen-associated molecular patterns such as lipopol

Updated on:April 22,2024

The promise of precision medicine for rheumatoid arthritis

by Yale UniversityA hand affected by rheumatoid arthritis. Credit: James Heilman, MD/WikipediaIn a new study, a Yale-led research team identified the mechanism of a gene that raises the risk of s

Updated on: May 13,2024

The promise of precision medicine for rheumatoid arthritis

by Yale UniversityA hand affected by rheumatoid arthritis. Credit: James Heilman, MD/WikipediaIn a new study, a Yale-led research team identified the mechanism of a gene that raises the risk of s

Updated on:May 13,2024