An antibody-drug combo to combat cancer

by Tokyo Medical and Dental UniversityCredit: Tokyo Medical and Dental UniversityLeukemias are debilitating cancers of the hematopoietic or blood-forming cells of the bone marrow. Now, researchers at

Updated on: May 05,2024 18

An antibody-drug combo to combat cancer

by Tokyo Medical and Dental UniversityCredit: Tokyo Medical and Dental UniversityLeukemias are debilitating cancers of the hematopoietic or blood-forming cells of the bone marrow. Now, researchers at

Updated on:May 05,2024 18

Study finds primary cilia restrict autoinflammation by mediating PD-L1 expression

by Science China PressLoss of primary cilia results in the downregulation of PD-L1 expression, which contributes to unrestrained local T cell proliferation and activation. Credit: Science China P

Updated on: June 15,2024 4

Study finds primary cilia restrict autoinflammation by mediating PD-L1 expression

by Science China PressLoss of primary cilia results in the downregulation of PD-L1 expression, which contributes to unrestrained local T cell proliferation and activation. Credit: Science China P

Updated on:June 15,2024 4

Socioeconomic factors linked to persistently active rheumatoid arthritis

by Elana GotkineSocioeconomic factors and deprivation are associated with persistently active rheumatoid arthritis (pactiveRA), according to a study published online July 14 inRMD Open.Maryam Ad

Updated on: July 23,2024 0

Socioeconomic factors linked to persistently active rheumatoid arthritis

by Elana GotkineSocioeconomic factors and deprivation are associated with persistently active rheumatoid arthritis (pactiveRA), according to a study published online July 14 inRMD Open.Maryam Ad

Updated on:July 23,2024 0

Study establishes IL-24 as a critical factor for onset and progression of atopic dermatitis

by Higher Education PressIL-24, which is expressed in keratinocytes and induced by S. aureus infection, promotes atopic dermatitis-like inflammation by enhancing a type 2 immune response. Credit: Xinm

Updated on: September 04,2024 0

Study establishes IL-24 as a critical factor for onset and progression of atopic dermatitis

by Higher Education PressIL-24, which is expressed in keratinocytes and induced by S. aureus infection, promotes atopic dermatitis-like inflammation by enhancing a type 2 immune response. Credit: Xinm

Updated on:September 04,2024 0

T cells: Vesicles strengthen immune response

by Ludwig Maximilian University of MunichMFG-E8-eGFP detects PS+ apoptotic and PS+ EV-decorated cells in vivo. Credit: Proceedings of the National Academy of Sciences (2023). DOI: 10.1073/pnas.22

Updated on: May 05,2024 14

T cells: Vesicles strengthen immune response

by Ludwig Maximilian University of MunichMFG-E8-eGFP detects PS+ apoptotic and PS+ EV-decorated cells in vivo. Credit: Proceedings of the National Academy of Sciences (2023). DOI: 10.1073/pnas.22

Updated on:May 05,2024 14

Investigators discover unique immune cells in patients with checkpoint inhibitor-induced arthritis

by Hospital for Special SurgeryCredit: CC0 Public DomainSince doctors began treating cancer patients with immunotherapy drugs called checkpoint inhibitors nearly a decade ago, they have observed

Updated on: June 17,2024 5

Investigators discover unique immune cells in patients with checkpoint inhibitor-induced arthritis

by Hospital for Special SurgeryCredit: CC0 Public DomainSince doctors began treating cancer patients with immunotherapy drugs called checkpoint inhibitors nearly a decade ago, they have observed

Updated on:June 17,2024 5

Patient-driven discovery reveals potential target for autoimmune diseases

by Isabella Backman,Yale UniversityModel summarizing the function of PI3Kγ in antibody responses. Credit:Nature Immunology(2024). DOI: 10.1038/s41590-024-01890-1A medical mystery ser

Updated on: July 17,2024 0

Patient-driven discovery reveals potential target for autoimmune diseases

by Isabella Backman,Yale UniversityModel summarizing the function of PI3Kγ in antibody responses. Credit:Nature Immunology(2024). DOI: 10.1038/s41590-024-01890-1A medical mystery ser

Updated on:July 17,2024 0

New device monitors levels of inflammation-associated C-reactive protein in real time

byPolish Academy of SciencesGraphical abstract. Credit:ACS Sensors(2024). DOI: 10.1021/acssensors.4c00249As inflammation is the body's natural immune response to disease or infec

Updated on: September 02,2024 0

New device monitors levels of inflammation-associated C-reactive protein in real time

byPolish Academy of SciencesGraphical abstract. Credit:ACS Sensors(2024). DOI: 10.1021/acssensors.4c00249As inflammation is the body's natural immune response to disease or infec

Updated on:September 02,2024 0

Unusual type of antibody shows ultrapotent activity against Zika

by Weill Cornell Medical CollegeZika virus particles (red) shown in African green monkey kidney cells. Credit: NIAIDAn unusual type of antibody that even at miniscule levels neutralizes the Zika

Updated on: May 07,2024 12

Unusual type of antibody shows ultrapotent activity against Zika

by Weill Cornell Medical CollegeZika virus particles (red) shown in African green monkey kidney cells. Credit: NIAIDAn unusual type of antibody that even at miniscule levels neutralizes the Zika

Updated on:May 07,2024 12

Recurrent wheezing in children linked to 'silent' viral infections

by Josh Barney,University of VirginiaNearly a quarter of children with recurrent wheezing suffer from lung infections that present no symptoms and should be treated with antiviral medications, U

Updated on: August 08,2024 0

Recurrent wheezing in children linked to 'silent' viral infections

by Josh Barney,University of VirginiaNearly a quarter of children with recurrent wheezing suffer from lung infections that present no symptoms and should be treated with antiviral medications, U

Updated on:August 08,2024 0

Loosening chimeric antigen receptor's grip on T-regulatory cells improves function, researchers find

by Leslie Cantu,Medical University of South CarolinaCAR and endogenous TCR/CD28 activation result in phenotypically similar Tregs. Credit:Molecular Therapy—Methods & Clinical Developme

Updated on: January 11,2025 0

Loosening chimeric antigen receptor's grip on T-regulatory cells improves function, researchers find

by Leslie Cantu,Medical University of South CarolinaCAR and endogenous TCR/CD28 activation result in phenotypically similar Tregs. Credit:Molecular Therapy—Methods & Clinical Developme

Updated on:January 11,2025 0

Running, even in excess, doesn't lead to more osteoarthritis and hip replacements

by Dan Krotz,Lawrence Berkeley National LaboratoryCredit: Berkeley Lab photographer Roy Kaltschmidt(Medical Xpress)—Need another reason to dust off those running shoes in the back of the closet?

Updated on: June 06,2024 5

Running, even in excess, doesn't lead to more osteoarthritis and hip replacements

by Dan Krotz,Lawrence Berkeley National LaboratoryCredit: Berkeley Lab photographer Roy Kaltschmidt(Medical Xpress)—Need another reason to dust off those running shoes in the back of the closet?

Updated on:June 06,2024 5