UTSW researchers developed an electrode grid that they placed on the backs of study participants to deliver low-voltage electrical stimulation through the skin. They found the device safe and easy to use in treating various spinal conditions and have filed for a patent. Credit: UT Southwestern Medical Center

A grid of electrodes placed on the backs of study participants delivered enough low-voltage electrical stimulation through the skin to change the short-term function of spinal cord neurons, a study led by UT Southwestern Medical Center researchers showed.

Their findings, published in the Journal of Neural Engineering, could lead to new approaches to treat pain, spasticity, and paralysis in patients, including those with spinal cord injuries and stroke, the authors said.

"The ability to differentially and noninvasively modulate spinal circuits offers a promising alternative for patients who are unable or unwilling to undergo invasive spinal stimulation procedures, " said Yasin Dhaher, Ph.D., Professor of Physical Medicine and Rehabilitation at UT Southwestern and an Investigator in the Peter O'Donnell Jr. Brain Institute. Dr. Dhaher co-led the study with UT Southwestern graduate student Hyungtaek "Tony" Kim, M.S.

Over the past decade, advances in techniques to stimulate the spinal cord with implanted electrodes have shown enormous potential, restoring one's ability to stand and walk even when the spinal cord is severed.

These devices, which work by modifying the activity of nerve cells with electricity, hold promise for treating neurological injuries and disease. However, Dr. Dhaher and Kim said, they carry the inherent risks of invasive spinal surgery—including potential infection and injury—and require a lengthy recovery period.

Some researchers have investigated delivering electrical stimulation to the spinal cord noninvasively through electrodes placed on the skin. However, early attempts using large surface pads spread current broadly across the back, so only a diffuse field reached the spinal segments that control leg muscles, achieving minimal or no results.

To create a "localized" field, Dr. Dhaher, Kim, and their colleagues developed an electrode grid featuring eight pairs of 1.27-centimeter anodes and cathodes arranged in a 4-by-4-inch array and attached to a biocompatible adhesive substrate. By altering which electrodes served as anodes or cathodes, the same patch could steer current either straight across (transverse layout) or diagonally across the thoracolumbar cord.

Because spinal neurons run in many directions, the team investigated field orientation that would interact most effectively with the lumbar circuits. Comparing the two layouts allowed them to see how subtle shifts in electric-field direction reshape spinal activity even with low currents.

The team recruited 17 healthy participants with an average age of about 29 to test the devices, centering the grid over the participants' 10th and 11th thoracic vertebrae. This corresponds to the portion of the spinal cord known to control the tibialis anterior (TA), a muscle that runs along the shin and controls ankle flexion.

After checking the participants' reflexes to confirm normal activity of the TA, the researchers delivered 40 milliamperes of electricity to the grid—about half what is needed to power the flashlight on a phone. Although this low voltage isn't enough to stimulate neurons to cause the TA to contract, Kim explained, it changed the neurons' excitability, or ability to fire.

The researchers found that this stimulation had an inhibitory effect, lowering excitability even 30 minutes after the researchers turned off the electrode grid. This inhibition was more pronounced when the researchers positioned the grid in a diagonal orientation with corners pointing up and down the spine, rather than a transverse orientation with edges at the top and bottom.

The device was safe and easy to use, Kim said, and changing its position could allow patients to personalize its effects to treat their conditions. Although this study investigated the electric field's inhibitory effects—which might be used to treat pain and spasticity—delivering electricity in other ways could make neurons more excitable, potentially enhancing patients' ability to flex muscles. Being able to flex the TA could remedy foot drop, Kim added, providing a new therapy to treat this common consequence of stroke.

The researchers plan to continue investigating this device and have filed for a patent.

More information: Hyungtaek Kim et al, Grid-based transcutaneous spinal cord stimulation: probing neuromodulatory effect in spinal flexion reflex circuits, Journal of Neural Engineering (2025). DOI: 10.1088/1741-2552/adc6bd  Journal information: Journal of Neural Engineering