Combining cholesterol-lowering statins with existing cancer drug shows potent effect against breast cancer subtype

by Katie Brace,Beth Israel Deaconess Medical CenterTN/ER-low PDOs are sensitive to combination AZD5363 and pitavastatin. A panel of breast cancer PDOs were treated with DMSO, 1 µM AZD5363, 5 µM

Updated on: August 26,2024 0

Combining cholesterol-lowering statins with existing cancer drug shows potent effect against breast cancer subtype

by Katie Brace,Beth Israel Deaconess Medical CenterTN/ER-low PDOs are sensitive to combination AZD5363 and pitavastatin. A panel of breast cancer PDOs were treated with DMSO, 1 µM AZD5363, 5 µM

Updated on:August 26,2024 0

FDA Approves Lymphir: A New Hope for CTCL Patients

The U.S. Food and Drug Administration (FDA) had approved Lymphir (denileukin diftitox-cxdl), a novel immunotherapy for the treatment of relapsed or refractory cutaneous T-cell lymphoma (CTCL) after at least one prior systemic therapy.

Updated on: August 12,2024 0

FDA Approves Lymphir: A New Hope for CTCL Patients

The U.S. Food and Drug Administration (FDA) had approved Lymphir (denileukin diftitox-cxdl), a novel immunotherapy for the treatment of relapsed or refractory cutaneous T-cell lymphoma (CTCL) after at least one prior systemic therapy.

Updated on:August 12,2024 0

Early disease detection in body fluids using photonic biosensors

by Anne-Julie Zichner, Fraunhofer-Institut für Photonische Mikrosysteme (IPMS)Photonic biosensor chip of Fraunhofer IPMS Credit: Fraunhofer IPMSStandard medical procedures are often time-consuming and

Updated on: August 08,2024 0

Early disease detection in body fluids using photonic biosensors

by Anne-Julie Zichner, Fraunhofer-Institut für Photonische Mikrosysteme (IPMS)Photonic biosensor chip of Fraunhofer IPMS Credit: Fraunhofer IPMSStandard medical procedures are often time-consuming and

Updated on:August 08,2024 0

A new drug target identified for diseases associated with leukemia-causing virus

by Christine Yu,Pennsylvania State UniversityKDR inhibition induces autophagic/lysosomal degradation of Tax. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-49737-5A team

Updated on: August 06,2024 0

A new drug target identified for diseases associated with leukemia-causing virus

by Christine Yu,Pennsylvania State UniversityKDR inhibition induces autophagic/lysosomal degradation of Tax. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-49737-5A team

Updated on:August 06,2024 0

The interaction between glucose and DDX21 in tissue differentiation and cancer metabolism

Updated on: August 03,2024 0

The interaction between glucose and DDX21 in tissue differentiation and cancer metabolism

Updated on:August 03,2024 0

Distinct signaling pathway identified as key driver for epithelial cancer development

by Kurt Bodenmüller,University of ZurichSide section of the skin with epidermal stem cells (green) with one particular clone in red. Cell nuclei are stained in blue, the white dashed lines indic

Updated on: August 03,2024 0

Distinct signaling pathway identified as key driver for epithelial cancer development

by Kurt Bodenmüller,University of ZurichSide section of the skin with epidermal stem cells (green) with one particular clone in red. Cell nuclei are stained in blue, the white dashed lines indic

Updated on:August 03,2024 0

Scientists develop first bone marrow model that supports human stem cells

byUniversity of GlasgowSchematic of the bone marrow (BM) niche microenvironment. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-50054-0Scientists have created the first

Updated on: August 03,2024 0

Scientists develop first bone marrow model that supports human stem cells

byUniversity of GlasgowSchematic of the bone marrow (BM) niche microenvironment. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-50054-0Scientists have created the first

Updated on:August 03,2024 0

Researchers discuss HER2-low and HER2-zero in breast cancer

by Impact Journals LLCMicrograph showing a lymph node invaded by ductal breast carcinoma, with extension of the tumor beyond the lymph node. Credit: Nephron/WikipediaA new editorial paper titled &quot

Updated on: August 03,2024 0

Researchers discuss HER2-low and HER2-zero in breast cancer

by Impact Journals LLCMicrograph showing a lymph node invaded by ductal breast carcinoma, with extension of the tumor beyond the lymph node. Credit: Nephron/WikipediaA new editorial paper titled &quot

Updated on:August 03,2024 0

Eliminating senescent cells could help treat breast, pancreatic cancers

byWashington University in St. LouisShown is a human breast tumor sample. The white arrows point to senescent cells in the tumor. Eliminating senescent cells, which drive inflammation, could bec

Updated on: August 03,2024 0

Eliminating senescent cells could help treat breast, pancreatic cancers

byWashington University in St. LouisShown is a human breast tumor sample. The white arrows point to senescent cells in the tumor. Eliminating senescent cells, which drive inflammation, could bec

Updated on:August 03,2024 0

Knockout of CD5 on CAR T cells shown to boost anti-tumor efficacy

byPerelman School of Medicine at the University of PennsylvaniaCD5 KO enhances CAR T cell cytotoxicity. Credit:Science Immunology(2024). DOI: 10.1126/sciimmunol.adn6509The effectiven

Updated on: August 03,2024 0

Knockout of CD5 on CAR T cells shown to boost anti-tumor efficacy

byPerelman School of Medicine at the University of PennsylvaniaCD5 KO enhances CAR T cell cytotoxicity. Credit:Science Immunology(2024). DOI: 10.1126/sciimmunol.adn6509The effectiven

Updated on:August 03,2024 0

Testosterone therapy may protect against breast cancer in trans masculine individuals

by Jacqueline Mitchell,Beth Israel Deaconess Medical Centera) Lobular atrophy was assessed by the pathologists using four categories. b) The duration of testosterone therapy (TT) significantly c

Updated on: August 03,2024 0

Testosterone therapy may protect against breast cancer in trans masculine individuals

by Jacqueline Mitchell,Beth Israel Deaconess Medical Centera) Lobular atrophy was assessed by the pathologists using four categories. b) The duration of testosterone therapy (TT) significantly c

Updated on:August 03,2024 0

Tumor-infiltrating lymphocyte therapy marks a milestone in cancer treatment, researchers say

byH. Lee Moffitt Cancer Center & Research InstituteCancer cell during cell division. Credit: National Institutes of HealthThe recent U.S. Food and Drug Administration approval of lifileucel,

Updated on: August 03,2024 0

Tumor-infiltrating lymphocyte therapy marks a milestone in cancer treatment, researchers say

byH. Lee Moffitt Cancer Center & Research InstituteCancer cell during cell division. Credit: National Institutes of HealthThe recent U.S. Food and Drug Administration approval of lifileucel,

Updated on:August 03,2024 0