Early clinical trial data show gene therapy reversing sickle cell anemia

by Cincinnati Children's Hospital Medical CenterTechnicians work in the ISO-certified cleanroom laboratory at Cincinnati Children's, where gene-correction therapies are tested and produce

Updated on: April 20,2024

Early clinical trial data show gene therapy reversing sickle cell anemia

by Cincinnati Children's Hospital Medical CenterTechnicians work in the ISO-certified cleanroom laboratory at Cincinnati Children's, where gene-correction therapies are tested and produce

Updated on:April 20,2024

Cancer screening and detection remain below prepandemic levels

At the end of 2021, population-based screening and diagnosis remained below prepandemic levels for breast, cervical, and colorectal cancers, according to a research letter published online Nov. 17 in&

Updated on: December 18,2023

Cancer screening and detection remain below prepandemic levels

At the end of 2021, population-based screening and diagnosis remained below prepandemic levels for breast, cervical, and colorectal cancers, according to a research letter published online Nov. 17 in&

Updated on:December 18,2023

New targets in the fight against pancreatic cancer

by Tokyo Medical and Dental UniversityTop, SETD1A, directly recruited to the RUVBL1 promoter, enhances RUVBL1 gene expression by increasing H3K4me3 levels in pancreatic cancer cells. Bottom, High co-e

Updated on: December 27,2023

New targets in the fight against pancreatic cancer

by Tokyo Medical and Dental UniversityTop, SETD1A, directly recruited to the RUVBL1 promoter, enhances RUVBL1 gene expression by increasing H3K4me3 levels in pancreatic cancer cells. Bottom, High co-e

Updated on:December 27,2023

The way genes are switched on in one-cell embryos may resemble the trigger for cancer

byUniversity of BathGraphical Abstract. Credit:Cell Reports(2023). DOI: 10.1016/j.celrep.2023.112023When an embryo is formed, its genes—donated by a fertilizing sperm and egg—are sil

Updated on: December 25,2023

The way genes are switched on in one-cell embryos may resemble the trigger for cancer

byUniversity of BathGraphical Abstract. Credit:Cell Reports(2023). DOI: 10.1016/j.celrep.2023.112023When an embryo is formed, its genes—donated by a fertilizing sperm and egg—are sil

Updated on:December 25,2023

Understanding early effects of psoriasis drug offers potential for personalized treatment

by King's College LondonDiagram showing the early effects of therapeutic IL-23 inhibition. Left: in lesional psoriasis skin, IL-23 drives the differentiation of T17 cells. Right: following IL

Updated on: May 06,2024

Understanding early effects of psoriasis drug offers potential for personalized treatment

by King's College LondonDiagram showing the early effects of therapeutic IL-23 inhibition. Left: in lesional psoriasis skin, IL-23 drives the differentiation of T17 cells. Right: following IL

Updated on:May 06,2024

Major response to immunotherapy in early-stage mismatch repair deficient colon cancer

byEuropean Society for Medical OncologyCredit:Annals of OncologyPre-operative treatment with a combination of the immune checkpoint inhibitors nivolumab and ipilimumab achieves major patho

Updated on: December 18,2023

Major response to immunotherapy in early-stage mismatch repair deficient colon cancer

byEuropean Society for Medical OncologyCredit:Annals of OncologyPre-operative treatment with a combination of the immune checkpoint inhibitors nivolumab and ipilimumab achieves major patho

Updated on:December 18,2023

Integrating mental health services into oncology treatment protocols

byThe City University of New YorkStudy participant is interviewed. Credit: The City University of New YorkA new study by CUNY SPH doctoral student Thinh Vu and colleagues reveals that cancer inp

Updated on: December 26,2023

Integrating mental health services into oncology treatment protocols

byThe City University of New YorkStudy participant is interviewed. Credit: The City University of New YorkA new study by CUNY SPH doctoral student Thinh Vu and colleagues reveals that cancer inp

Updated on:December 26,2023

Unveiling the non-canonical functions of EZH2 in prostate cancer

by Impact Journals LLCProstate cancer cells. Credit: NIH Image GalleryA new editorial paper was published inOncotargettitled "Unveiling the non-canonical functions of EZH2 in prostate

Updated on: December 26,2023

Unveiling the non-canonical functions of EZH2 in prostate cancer

by Impact Journals LLCProstate cancer cells. Credit: NIH Image GalleryA new editorial paper was published inOncotargettitled "Unveiling the non-canonical functions of EZH2 in prostate

Updated on:December 26,2023

The use of DNA biomarkers for detecting early-stage HPV-positive oropharynx cancers has limitations

byBrigham and Women's HospitalA double stranded DNA fragment. Credit: Vcpmartin/Wikimedia/ CC BY-SA 4.0Oropharynx cancers caused by human papillomavirus (HPV) have risen dramatically over th

Updated on: January 04,2024

The use of DNA biomarkers for detecting early-stage HPV-positive oropharynx cancers has limitations

byBrigham and Women's HospitalA double stranded DNA fragment. Credit: Vcpmartin/Wikimedia/ CC BY-SA 4.0Oropharynx cancers caused by human papillomavirus (HPV) have risen dramatically over th

Updated on:January 04,2024

Genetic test could guide use of cancer chemotherapy

by Ellie Cawthera,Imperial College LondonDiscovery ofKRASG12mutation status as potential biomarker of outcome of FTD/TPI treatment in mCRC.a, Dot plot showing the associations

Updated on: December 25,2023

Genetic test could guide use of cancer chemotherapy

by Ellie Cawthera,Imperial College LondonDiscovery ofKRASG12mutation status as potential biomarker of outcome of FTD/TPI treatment in mCRC.a, Dot plot showing the associations

Updated on:December 25,2023

Quantitative pathologic analysis may help predict prognosis in colorectal cancer

The quantitative segmentation algorithm (QuantCRC) may improve the prediction of prognosis in colorectal cancer (CRC), according to a study published online Aug. 16 inGastroenterology.Reetesh K.

Updated on: December 20,2023

Quantitative pathologic analysis may help predict prognosis in colorectal cancer

The quantitative segmentation algorithm (QuantCRC) may improve the prediction of prognosis in colorectal cancer (CRC), according to a study published online Aug. 16 inGastroenterology.Reetesh K.

Updated on:December 20,2023

Looking at the environment around tumors could help predict how cancer spreads

byUniversity College LondonRepresentative images of high granulocyte infiltration in the tumor nest and stroma for LUAD (left) and LUSC (right). Credit:Cancer Discovery(2024). DOI: 1

Updated on: April 28,2024

Looking at the environment around tumors could help predict how cancer spreads

byUniversity College LondonRepresentative images of high granulocyte infiltration in the tumor nest and stroma for LUAD (left) and LUSC (right). Credit:Cancer Discovery(2024). DOI: 1

Updated on:April 28,2024