New screening tool to explore mechanisms behind cancer, autoimmunity and neurodegeneration

by Jelena Pupavac,Wellcome Trust Sanger InstituteA single-cell base editor screen tiling acrossJAK1is improved by coupling genotype with transcriptome.aUMAP of LoF and no

Updated on: April 23,2024 0

New screening tool to explore mechanisms behind cancer, autoimmunity and neurodegeneration

by Jelena Pupavac,Wellcome Trust Sanger InstituteA single-cell base editor screen tiling acrossJAK1is improved by coupling genotype with transcriptome.aUMAP of LoF and no

Updated on:April 23,2024 0

Overall burden of tumor genome changes can predict patient outcomes

by eLifeKiller T cells surround a cancer cell. Credit: NIHResearchers have discovered a link between certain changes in the genome of a tumor and increased chances of death across multiple types

Updated on: April 09,2024 16

Overall burden of tumor genome changes can predict patient outcomes

by eLifeKiller T cells surround a cancer cell. Credit: NIHResearchers have discovered a link between certain changes in the genome of a tumor and increased chances of death across multiple types

Updated on:April 09,2024 16

Analysis calculates $725M in economic potential from expanded cancer treatment access

by Katja Wie, WifORRatio of cost of treatment to GDP per capita. Credit:The Lancet OncologyCommissionA recent analysis,publishedinThe Lancet Oncology, calculates that inc

Updated on: October 24,2024 0

Analysis calculates $725M in economic potential from expanded cancer treatment access

by Katja Wie, WifORRatio of cost of treatment to GDP per capita. Credit:The Lancet OncologyCommissionA recent analysis,publishedinThe Lancet Oncology, calculates that inc

Updated on:October 24,2024 0

Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma

by OncotargetElevated HDAC2 mRNA expression is poorly prognostic in DDLPS. (A) mRNA expression of HDAC2 and disease-free survival (DFS) data from 52 subjects with DDLPS from The Cancer Genome Atlas (T

Updated on: May 11,2024 6

Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma

by OncotargetElevated HDAC2 mRNA expression is poorly prognostic in DDLPS. (A) mRNA expression of HDAC2 and disease-free survival (DFS) data from 52 subjects with DDLPS from The Cancer Genome Atlas (T

Updated on:May 11,2024 6

Researchers identify key metabolic regulators of drug resistance in the fight against pancreatic cancer

by Rebecca Brierley,University at BuffaloGraphical abstract. Credit:Molecular & Cellular Proteomics(2022). DOI: 10.1016/j.mcpro.2022.100409Researchers from the University at Buff

Updated on: February 20,2024 17

Researchers identify key metabolic regulators of drug resistance in the fight against pancreatic cancer

by Rebecca Brierley,University at BuffaloGraphical abstract. Credit:Molecular & Cellular Proteomics(2022). DOI: 10.1016/j.mcpro.2022.100409Researchers from the University at Buff

Updated on:February 20,2024 17

ASCO: Low-fat dietary pattern cuts breast cancer deaths

(HealthDay)—A low-fat dietary intervention is associated with reductions in deaths after breast cancer and deaths from breast cancer among postmenopausal women after long-term follow-up, according to

Updated on: March 30,2024 11

ASCO: Low-fat dietary pattern cuts breast cancer deaths

(HealthDay)—A low-fat dietary intervention is associated with reductions in deaths after breast cancer and deaths from breast cancer among postmenopausal women after long-term follow-up, according to

Updated on:March 30,2024 11

Shades of grey reveal breast tumours

by David Bradley,InderscienceMammograms showing a normal breast (left) and a breast with cancer (right). Credit: Public DomainBreast cancer is the second most common cancer in women. Mammography

Updated on: March 01,2024 17

Shades of grey reveal breast tumours

by David Bradley,InderscienceMammograms showing a normal breast (left) and a breast with cancer (right). Credit: Public DomainBreast cancer is the second most common cancer in women. Mammography

Updated on:March 01,2024 17

Incoming New Zealand govt to abandon anti-smoking laws

Credit: CC0 Public DomainNew Zealand's incoming conservative government will jettison world-leading measures to stub out smoking, new Prime Minister Christopher Luxon confirmed Monday, in a move d

Updated on: March 06,2024 13

Incoming New Zealand govt to abandon anti-smoking laws

Credit: CC0 Public DomainNew Zealand's incoming conservative government will jettison world-leading measures to stub out smoking, new Prime Minister Christopher Luxon confirmed Monday, in a move d

Updated on:March 06,2024 13

Research quantifies effect of chronic diseases on racial disparity in COVID-associated hospitalizations

by Louisiana State UniversityCredit: CC0 Public DomainLSU Health New Orleans conducted the first research using disease surveillance data to quantify the effect of chronic diseases on racial disp

Updated on: June 28,2024 8

Research quantifies effect of chronic diseases on racial disparity in COVID-associated hospitalizations

by Louisiana State UniversityCredit: CC0 Public DomainLSU Health New Orleans conducted the first research using disease surveillance data to quantify the effect of chronic diseases on racial disp

Updated on:June 28,2024 8

Epigenetic mechanism associated with clinical outcome and therapeutic vulnerability in liver cancer

by Josep Carreras Leukaemia Research InstituteNSUN7 epigenetic loss occurs in human primary HCC tumors in association with worse clinical outcome. (A) Percentage of NSUN7 methylation in the TCGA

Updated on: February 18,2024 19

Epigenetic mechanism associated with clinical outcome and therapeutic vulnerability in liver cancer

by Josep Carreras Leukaemia Research InstituteNSUN7 epigenetic loss occurs in human primary HCC tumors in association with worse clinical outcome. (A) Percentage of NSUN7 methylation in the TCGA

Updated on:February 18,2024 19

Researchers uncover potential biomarkers of positive response to immunotherapy

by Denise Heady,University of California, Los AngelesResponse to ICI or MAPKi therapy is associated with increased T cell infiltration and enhanced interferon gamma (IFNγ) pathway activity in th

Updated on: January 30,2024 16

Researchers uncover potential biomarkers of positive response to immunotherapy

by Denise Heady,University of California, Los AngelesResponse to ICI or MAPKi therapy is associated with increased T cell infiltration and enhanced interferon gamma (IFNγ) pathway activity in th

Updated on:January 30,2024 16

Researchers show that using a tumor's own bacteria is a promising anticancer therapy

by Japan Advanced Institute of Science and TechnologyA bacterial consortium consisting of A-gyo, UN-gyo, and AUN has high anticancer efficacy, triggering the immune system to attack tumor cells. Credi

Updated on: February 24,2024 11

Researchers show that using a tumor's own bacteria is a promising anticancer therapy

by Japan Advanced Institute of Science and TechnologyA bacterial consortium consisting of A-gyo, UN-gyo, and AUN has high anticancer efficacy, triggering the immune system to attack tumor cells. Credi

Updated on:February 24,2024 11