Study reveals insights into DDX41 protein's role in blood cancer pathogenesis

by JooHyeon Heo,Ulsan National Institute of Science and TechnologyA schematic image showing the impact of DDX41 mutations on MDS patients. Credit: Won Chan Hwang et al/Ulsan National Institute o

Updated on: April 28,2024 0

Study reveals insights into DDX41 protein's role in blood cancer pathogenesis

by JooHyeon Heo,Ulsan National Institute of Science and TechnologyA schematic image showing the impact of DDX41 mutations on MDS patients. Credit: Won Chan Hwang et al/Ulsan National Institute o

Updated on:April 28,2024 0

Natural mechanism causes 50-fold increase in T-cell activation sensitivity

byLatrobe UniversityThymic cortical T cell deletion induced by a CDR3 cysteine. TCR-retrogenic mice expressing the 6218 or 6218αC TCR were made as described in Fig.1, except that all recip

Updated on: January 22,2024 18

Natural mechanism causes 50-fold increase in T-cell activation sensitivity

byLatrobe UniversityThymic cortical T cell deletion induced by a CDR3 cysteine. TCR-retrogenic mice expressing the 6218 or 6218αC TCR were made as described in Fig.1, except that all recip

Updated on:January 22,2024 18

Computational tool integrates transcriptomic data to enhance breast cancer diagnosis and treatment

by Nik Papageorgiou,Ecole Polytechnique Federale de LausanneClinical validation of EMBER. Credit:npj Breast Cancer(2024). DOI: 10.1038/s41523-024-00665-zAddressing problems with diag

Updated on: August 03,2024 0

Computational tool integrates transcriptomic data to enhance breast cancer diagnosis and treatment

by Nik Papageorgiou,Ecole Polytechnique Federale de LausanneClinical validation of EMBER. Credit:npj Breast Cancer(2024). DOI: 10.1038/s41523-024-00665-zAddressing problems with diag

Updated on:August 03,2024 0

Study uncovers role of ultraviolet radiation in development of rare leukemia in the skin

by Dana-Farber Cancer InstituteSkin tumor (top) from a representative patient with BPDCN showing infiltration by malignant cells (haematoxylin and eosin (H&E), left) expressing the pDC marker

Updated on: February 23,2024 11

Study uncovers role of ultraviolet radiation in development of rare leukemia in the skin

by Dana-Farber Cancer InstituteSkin tumor (top) from a representative patient with BPDCN showing infiltration by malignant cells (haematoxylin and eosin (H&E), left) expressing the pDC marker

Updated on:February 23,2024 11

Study suggests chromosomal errors may hinder some aggressive tumors

by Julie Vera,Mayo ClinicGraphical abstract. Credit:Cell Reports Medicine(2023). DOI: 10.1016/j.xcrm.2023.100937Chromosomal errors are a hallmark of cancer cells. Defects in the geno

Updated on: January 22,2024 14

Study suggests chromosomal errors may hinder some aggressive tumors

by Julie Vera,Mayo ClinicGraphical abstract. Credit:Cell Reports Medicine(2023). DOI: 10.1016/j.xcrm.2023.100937Chromosomal errors are a hallmark of cancer cells. Defects in the geno

Updated on:January 22,2024 14

Specialised molecular profiling could allow more accurate prognosis and treatment of brain tumours

by Medical University of ViennaCredit: CC0 Public DomainMeningiomas, a type of brain tumour, are usually easy to treat. However, there are a few subtypes that follow a very aggressive course and

Updated on: April 01,2024 11

Specialised molecular profiling could allow more accurate prognosis and treatment of brain tumours

by Medical University of ViennaCredit: CC0 Public DomainMeningiomas, a type of brain tumour, are usually easy to treat. However, there are a few subtypes that follow a very aggressive course and

Updated on:April 01,2024 11

Fecal microbe transplants help cancer patients respond to immunotherapy and shrink tumors

by Diwakar Davar,The ConversationCancer patients who responded well to immunotherapy donated stool samples. Their stool was processed to yield material for a fecal microbe transplant. Credit: Di

Updated on: June 22,2024 7

Fecal microbe transplants help cancer patients respond to immunotherapy and shrink tumors

by Diwakar Davar,The ConversationCancer patients who responded well to immunotherapy donated stool samples. Their stool was processed to yield material for a fecal microbe transplant. Credit: Di

Updated on:June 22,2024 7

Researchers develop AI model to improve tumor removal accuracy during breast cancer surgery

by University of North Carolina at Chapel Hill School of Medicine(A) Diagram of model structure. (B) Flowchart of study design. Credit:Annals of Surgical Oncology(2023). DOI: 10.1245/

Updated on: January 30,2024 19

Researchers develop AI model to improve tumor removal accuracy during breast cancer surgery

by University of North Carolina at Chapel Hill School of Medicine(A) Diagram of model structure. (B) Flowchart of study design. Credit:Annals of Surgical Oncology(2023). DOI: 10.1245/

Updated on:January 30,2024 19

Genetic test identifies patients with triple negative breast cancer who are unlikely to respond to immunotherapies

by European Organisation for Research and Treatment of CancerProfessor Laura van 't Veer presented latest results from the I-SPY2 phase 2 clinical trial at the 14th European Breast Cancer Conferen

Updated on: March 30,2024 0

Genetic test identifies patients with triple negative breast cancer who are unlikely to respond to immunotherapies

by European Organisation for Research and Treatment of CancerProfessor Laura van 't Veer presented latest results from the I-SPY2 phase 2 clinical trial at the 14th European Breast Cancer Conferen

Updated on:March 30,2024 0

Researchers uncover racial and ethnic disparities in a widely used precision oncology data registry

by Katie Marquedant,Massachusetts General HospitalSample size estimation to detect differences in mutational proportions between white and racial/ethnic minority patients at varying power increm

Updated on: February 18,2024 16

Researchers uncover racial and ethnic disparities in a widely used precision oncology data registry

by Katie Marquedant,Massachusetts General HospitalSample size estimation to detect differences in mutational proportions between white and racial/ethnic minority patients at varying power increm

Updated on:February 18,2024 16

Researchers determine oral bacteria accelerate pancreatic cancer development in mice

by Hebrew University of JerusalemPancreas sections from control and P.gingivalis-infected mice. Control mouse showing a small pre-cancerous lesion (marked in yellow). Credit: Hebrew University of

Updated on: March 30,2024 0

Researchers determine oral bacteria accelerate pancreatic cancer development in mice

by Hebrew University of JerusalemPancreas sections from control and P.gingivalis-infected mice. Control mouse showing a small pre-cancerous lesion (marked in yellow). Credit: Hebrew University of

Updated on:March 30,2024 0

Lactate-producing bacteria inside tumors found to promote resistance to radiation therapy

by University of Texas M. D. Anderson Cancer CenterGraphical Abstract. Credit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.09.012Researchers at The University of Texas MD Anderson Can

Updated on: April 09,2024 15

Lactate-producing bacteria inside tumors found to promote resistance to radiation therapy

by University of Texas M. D. Anderson Cancer CenterGraphical Abstract. Credit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.09.012Researchers at The University of Texas MD Anderson Can

Updated on:April 09,2024 15