Modular chimeric cytokine receptors improve CAR T-cell therapy for solid tumors

bySt. Jude Children's Research HospitalTwo leucine zipper motifs endow ZipRs with constitutive signal transduction.a, Schematic of IL-2 receptor-based Zip2Rs with phosphorylated (p) JA

Updated on: January 26,2024

Modular chimeric cytokine receptors improve CAR T-cell therapy for solid tumors

bySt. Jude Children's Research HospitalTwo leucine zipper motifs endow ZipRs with constitutive signal transduction.a, Schematic of IL-2 receptor-based Zip2Rs with phosphorylated (p) JA

Updated on:January 26,2024

Defensive beliefs likely keep people from taking at-home stool tests that screen for colorectal cancer

byWileyCancer—Histopathologic image of colonic carcinoid. Credit: Wikipedia/CC BY-SA 3.0Colorectal cancer is one of the most treatable cancers, especially if it is detected early; however, many

Updated on: December 22,2023

Defensive beliefs likely keep people from taking at-home stool tests that screen for colorectal cancer

byWileyCancer—Histopathologic image of colonic carcinoid. Credit: Wikipedia/CC BY-SA 3.0Colorectal cancer is one of the most treatable cancers, especially if it is detected early; however, many

Updated on:December 22,2023

Cancer test shows promise for bringing the benefits of immunotherapy to more patients

byBrigham and Women’s HospitalCredit: Pixabay/CC0 Public DomainImmunotherapy is a highly effective treatment for patients whose cancers harbor mismatch repair deficiency, and a new study identif

Updated on: January 25,2024

Cancer test shows promise for bringing the benefits of immunotherapy to more patients

byBrigham and Women’s HospitalCredit: Pixabay/CC0 Public DomainImmunotherapy is a highly effective treatment for patients whose cancers harbor mismatch repair deficiency, and a new study identif

Updated on:January 25,2024

As cancer treatment advances, patients and doctors push back against drugs' harsh side effects

by Carla K. JohnsonJill Feldman, 54, poses for a photo at her home in Deerfield, Ill., Friday, Jan. 19, 2024. Lung cancer patient and advocate Jill Feldman takes pills at home that shrink tumors by bl

Updated on: June 25,2024

As cancer treatment advances, patients and doctors push back against drugs' harsh side effects

by Carla K. JohnsonJill Feldman, 54, poses for a photo at her home in Deerfield, Ill., Friday, Jan. 19, 2024. Lung cancer patient and advocate Jill Feldman takes pills at home that shrink tumors by bl

Updated on:June 25,2024

Gene signature points to prognosis in kidney cancer

byKarolinska InstitutetSingle-cell landscape of the ecosystem in primary ccRCC and adjacent normal tissue.aExperimental design created with Biorender.com and Adobe Illustrator.

Updated on: December 25,2023

Gene signature points to prognosis in kidney cancer

byKarolinska InstitutetSingle-cell landscape of the ecosystem in primary ccRCC and adjacent normal tissue.aExperimental design created with Biorender.com and Adobe Illustrator.

Updated on:December 25,2023

New weight loss medication may help lower blood pressure in adults with obesity

by American Heart AssociationCredit: CC0 Public DomainThe new weight loss medication tirzepatide significantly lowered the systolic blood pressure (the top number in a blood pressure reading) for

Updated on: May 16,2024

New weight loss medication may help lower blood pressure in adults with obesity

by American Heart AssociationCredit: CC0 Public DomainThe new weight loss medication tirzepatide significantly lowered the systolic blood pressure (the top number in a blood pressure reading) for

Updated on:May 16,2024

Exploring the biology of 'double positive' T cells

byLudwig Cancer ResearchCredit: CC0 Public DomainThe molecular markers CD4 and CD8—defining helper T cells and killer T cells, respectively—were once considered mutually exclusive. But "dou

Updated on: January 07,2024

Exploring the biology of 'double positive' T cells

byLudwig Cancer ResearchCredit: CC0 Public DomainThe molecular markers CD4 and CD8—defining helper T cells and killer T cells, respectively—were once considered mutually exclusive. But "dou

Updated on:January 07,2024

New drug combinations could improve therapies for breast cancer, other aggressive cancers

by Angela Yeager,Oregon Health & Science UniversityQuantification of CD8+T cells by multispectral flow cytometry in an ex vivo co-culture assay. Credit:Cell Reports Medicine&nbsp

Updated on: September 10,2024

New drug combinations could improve therapies for breast cancer, other aggressive cancers

by Angela Yeager,Oregon Health & Science UniversityQuantification of CD8+T cells by multispectral flow cytometry in an ex vivo co-culture assay. Credit:Cell Reports Medicine&nbsp

Updated on:September 10,2024

In preclinical studies, team identifies potential therapy for metastatic colon cancer

by Weill Cornell Medical CollegeMultiplex immunofluorescence image of hyaluronan-rich human colorectal cancer. Highly aggressive tumoral cells (turquoise and magenta) are negative for both aPKCs

Updated on: February 24,2024

In preclinical studies, team identifies potential therapy for metastatic colon cancer

by Weill Cornell Medical CollegeMultiplex immunofluorescence image of hyaluronan-rich human colorectal cancer. Highly aggressive tumoral cells (turquoise and magenta) are negative for both aPKCs

Updated on:February 24,2024

Combination immunotherapy produces high response rate in early results of trial targeting high-risk follicular lymphoma

byUniversity of Miami Leonard M. Miller School of MedicineCancer cell during cell division. Credit: National Institutes of HealthResearchers conducting a Phase 2 clinical trial at Sylvester Comp

Updated on: January 26,2024

Combination immunotherapy produces high response rate in early results of trial targeting high-risk follicular lymphoma

byUniversity of Miami Leonard M. Miller School of MedicineCancer cell during cell division. Credit: National Institutes of HealthResearchers conducting a Phase 2 clinical trial at Sylvester Comp

Updated on:January 26,2024

Marijuana component offers opioid alternative by effectively treating dental pain

by Andrew Smith,Rutgers UniversityCBD reduced the dental pain and increased the bite force in patients presented with emergency toothache. (A) Median visual analog scale (VAS) pain scores per ti

Updated on: March 25,2024

Marijuana component offers opioid alternative by effectively treating dental pain

by Andrew Smith,Rutgers UniversityCBD reduced the dental pain and increased the bite force in patients presented with emergency toothache. (A) Median visual analog scale (VAS) pain scores per ti

Updated on:March 25,2024

SABCS: Long-term outcomes good for PBI in early breast cancer

(HealthDay)—For patients with early-stage breast cancer, 10-year outcomes are similar for treatment with partial breast irradiation (PBI) and whole breast irradiation (WBI), according to a study prese

Updated on: December 22,2023

SABCS: Long-term outcomes good for PBI in early breast cancer

(HealthDay)—For patients with early-stage breast cancer, 10-year outcomes are similar for treatment with partial breast irradiation (PBI) and whole breast irradiation (WBI), according to a study prese

Updated on:December 22,2023